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Stop using metformin and pioglitazone and get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Your doctor may want you to stop taking pioglitazone for a short time if any of these situations affect you. Some women using pioglitazone have started having menstrual periods, even after not having a period for a long time due to a medical condition. Anemia was reported more frequently when pioglitazone was combined with insulin, a sulfonylurea or metformin. In addition to a stable dose of metformin, pioglitazone, glimepiride, or glimepiride and metformin, patients whose diabetes was not adequately controlled were given either Januvia 100

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