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In controlled clinical trials, discontinuation of Avalide therapy due to clinical adverse events was required in only 3. If oligohydramnios occurs in these situations, individualized decisions about continuing or discontinuing Avalide treatment and about pregnancy management should be made by the patient, her physician, and experts in the management of high risk pregnancy. In patients with essential hypertension treated with Avalide alone, one patient was discontinued due to elevated liver enzymes. These initial study regimens were increased at 2 weeks to Avalide 300/25

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