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After discontinuation of Xalatan, pigmentation of the iris is likely to be permanent while pigmentation of the periorbital tissue and eyelash changes have been reported to be reversible in some patients. Xalatan should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Xalatan should be used with caution in patients who do not have an intact posterior capsule or who have known risk factors for macular edema. The events, which have been chosen for inclusion due to either their seriousness, frequency of reporting, possible causal connection to Xalatan, or a combination of these factors, include: asthma and exacerbation of asthma; corneal edema and erosions; dyspnea; eyelash and vellus hair changes (increased length, thickness, pigmentation, and number); eyelid skin darkening; herpes keratitis; intraocular inflammation (iritis/uveitis); keratitis; macular edema, including cystoid macular edema; misdirected eyelashes sometimes resulting in eye irritation; dizziness, headache, and toxic epidermal necrolysis. Xalatan is used to treat the following conditions: Glaucoma, Open Angle, Intraocular Hypertension. Xalatan is a member of the drug class ophthalmic glaucoma agents. Patients should also be informed about the possibility of eyelid skin darkening, which may be reversible after discontinuation of Xalatan. While treatment with Xalatan can be continued in patients who develop noticeably increased iris pigmentation, these patients should be examined regularly. Pigmentation is expected to increase as long as Xalatan is administered. Lenses may be reinserted 15 minutes following administration of Xalatan. Because many drugs are excreted in human milk, caution should be exercised when Xalatan is administered to a nursing woman.

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