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For those who received oral fluconazole, the median duration of oral therapy was 7 days for the Eraxis arm and 5 days for the fluconazole arm. Of these, 219 patients (116 Eraxis, 103 fluconazole) had candidemia only. 6%) of the fluconazole-treated group at the end of therapy. The apparent volume of distribution of fluconazole approximates that of total body water. 0% of subjects receiving Eraxis or fluconazole therapy in the comparative candidemia study. Following administration of 200 mg of fluconazole, the mean percentage increase of AUC for levonorgestrel compared to placebo was 25% (range: -12 to 82%) and the mean percentage increase for ethinyl estradiol compared to placebo was 38% (range: -11 to 101%). 8 % fluconazole-treated) switched to oral fluconazole after the end of IV therapy. In addition, creatinine clearance (74 mL/min), the percent of drug recovered unchanged in urine (0 to 24 hr, 22%) and the fluconazole renal clearance estimates (0. In this placebo-controlled, double-blind, randomized, two-way crossover study carried out over three cycles of oral contraceptive treatment, fluconazole dosing resulted in small increases in the mean AUCs of ethinyl estradiol and norethindrone compared to similar placebo dosing. 08 mcg/mL) and after single oral doses of 50 to 400 mg, fluconazole plasma concentrations and AUC (area under the plasma concentration-time curve) are dose proportional. In patients with bronchiectasis, sputum concentrations of fluconazole following a single 150 mg oral dose were equal to plasma concentrations at both 4 and 24 hours post dose. Three hundred patients received Eraxis (100 mg loading dose IV on Day 1 followed by 50 mg/day IV) and 301 received oral fluconazole (200 mg loading dose on Day 1 followed by 100 mg/day). The median duration of IV therapy was 14 and 11 days in the Eraxis and fluconazole arms, respectively. Patients were randomized to receive once daily IV Eraxis (200 mg loading dose followed by 100 mg maintenance dose) or IV fluconazole (800 mg loading dose followed by 400 mg maintenance dose). The treatment cycles were one month apart with all subjects receiving fluconazole during one cycle and placebo during the other. After the administration of cimetidine, there was a significant decrease in fluconazole AUC and Cmax. In patients with fungal meningitis, fluconazole concentrations in the CSF are approximately 80% of the corresponding plasma concentrations. Patients in both study arms were permitted to switch to oral fluconazole after at least 10 days of intravenous therapy, provided that they were able to tolerate oral medication, were afebrile for at least 24 hours, and the last blood cultures were negative for Candida species. According to the product labeling for rosuvastatin, fluconazole (200 mg once a day for 11 days) increased the area under the plasma concentration-time curve (AUC) of an 80 mg dose of rosuvastatin by 14%. Following either single- or multiple-oral doses for up to 14 days, fluconazole penetrates into all body fluids studied (see table below). fluconazole, two non-comparative) assessed the efficacy and safety of Eraxis (100 mg) in patients with candidemia and other Candida infections.

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